Jeremiah lives in a post-apocalyptic world following "The Big Death," a mysterious but devastating plague which claimed the lives of billions of people -- everyone above the age of puberty.
The world, for this generation of lost children, was shattered forever when they were forced to bury their parents. Life has become a bleak and seemingly soulless attempt to stay alive - to plunder, forage or barter for food and clothes and to seek out the sordid and fleeting pleasures that briefly distract them from their lives of terror and savage desperation.
Fifteen years have gone by since the world "ended" -- literally for one generation, symbolically for Jeremiah's generation. Jeremiah (Luke Perry), is twenty-seven, cynical, cautious and intense. He is one of the few left with a conscience and with a sense of debt to his dead parents and the brother whom he unwittingly let die in the chaotic aftermath of the epidemic. He is grimly determined to find the location of the "Valhalla Sector" which his father spoke about shortly before he died. He is also determined to help those less fortunate than he, as a vindication for his brother's death