U. S. Secret Service Agents Pete Lattimer and Myka Bering have just foiled a bizarre plot to assassnate the president of the United States, which would have involved him being possessed by a museum exhibit.
Following their success the pair are re-assigned to a top secret warehouse out in the middle of nowhere somewhere in South Dakota by a mysterious woman called Mrs. Frederic. The huge warehouse is stacked floor to ceiling with supernatural archifacts which have been collected throughout the history of North America. Naming it America's Attic it is looked after by a geeky little fellow called Artie Nielsen.
Agents Lattimer and Bering have now become representatives of Warehouse 13 and they are charged with continuing the job of tracking down and neutralising paranormal objects while reporting back to Artie at the warehouse on what they find.